变革性分子前沿科学中心

凌 代 舜 教 授 课 题 组

133. Fangyuan Li^#, Heng Sun^#, Jiafeng Ren^#, Bo Zhang^#, Xi Hu, Chunyan Fang, Jiyoung Lee, Hongzhou Gu, Daishun Ling*, A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance, Nature Communications, 2022, 13 (1), 1-16.

132. Xi Hu^#, Yu Sun^#, Xiaoqi Zhou, Bo Zhang, Hanxi Guan, Fan Xia, Shuangying Gui, Xueqian Kong, Fangyuan Li*, and Daishun Ling*, Insight into drug loading regulated micellar rigidity by nuclear magnetic resonance, ACS Nano, 2022, 16 (12), 21407-21416.

131. Hui Du^#, Qiyue Wang^#, Zeyu Liang, Qilong Li, Fangyuan Li^*, Daishun Ling^*. Designed fabrication of magnetic nanoprobes for ultra-high-field magnetic resonance imaging, Nanoscale, 2022, 14 (47), 17483-17499.

130. Guanhua Xu, Mengmeng Li, Qiyue Wang, Feng Feng, Qi Lou, Yi Hou, Junfeng Hui, Peisen Zhang, Li Wang, Li Yao*, Shijie Qin, Xiaoping Ouyang, Dazhuan Wu, Daishun Ling* and Xiuyu Wang*. A dual-kinetic control strategy for designing nano-metamaterials：novel class of metamaterials with both characteristic and whole sizes of nanoscale, Advanced science, 2022, 2205595.

129. Lingxiao Zhang^#, Jing Zhao^#, Xi Hu^#, Chenhan Wang^#, Yingbo Jia, Chaojie Zhu, Shangzhi Xie, Jiyoung Lee, Fangyuan Li^*, and Daishun Ling^*. A peritumorally injected immunomodulating adjuvant elicits robust and safe metalloimmunotherapy against solid tumors, Advanced Materials, 2022, 2206915.

116. Qinjie Weng^#, Heng Sun^#, Chunyan Fang^#, Fan Xia, Hongwei Liao, Jiyoung Lee, Jincheng Wang, An Xie, Jiafeng Ren, Xia Guo, Fangyuan Li, Bo Yang, Daishun Ling^*. Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics, Nature Communications, 2021, 12, 1436.

115. Heng Sun^#, Yan Zhong^#, Xiandi Zhu^#, Hongwei Liao^#, Jiyoung Lee, Ying Chen, Lijuan Ma, Jiafeng Ren, Meng Zhao, Mengjiao Tu, Fangyuan Li, Hong Zhang, Mei Tian^*, Daishun Ling^*. A tauopathy-homing and autophagy-activating nanoassembly for specific clearance of pathogenic tau in alzheimer's disease. ACS Nano, 2021, 15(3), 5263-5275.

114. Anran Yuan^#, Fan Xia^#, Qiong Bian, Haibin Wu, Yueting Gu, Tao Wang, Ruxuan Wang, Lingling Huang, Qiaoling Huang, Yuefeng Rao, Daishun Ling, Fangyuan Li^*, Jianqing Gao^*. Ceria nanozymes-integrated microneedles reshape the perifollicular microenvironment for androgenetic alopecia treatment, ACS Nano, 2021, 15(8), 13759-13769.

113. Peihua Lin^#, Mengda Cao^#, Fan Xia, Hongwei Liao, Heng Sun, Qiyue Wang, Jiyoung Lee, Yan Zhou, Yunan Guan, Cheng Zhang, Zhiqiang Xu, Fangyuan Li^*, Ji-Fu Wei^*, Daishun Ling^*. A phosphatase-mimetic nano-stabilizer of mast cells for long-term prevention of allergic disease, Advanced Science, 2021, 8(8), 2004115.

112. Ting Huang^# , Tianyuan Zhang^#* , Xinchi Jiang, Ai Li, Yuanqin Su, Qiong Bian, Honghui Wu, Ruyi Lin, Ni Li, Hongcui Cao, Daishun Ling, Jinqiang Wang, Yasuhiko Tabata, Zhen Gu^*, Jianqing Gao^*. Iron oxide nanoparticles augment the intercellular mitochondrial transfer–mediated therapy, Science Advances, 2021, 7(40), eabj0534.

111. Seungyong Shin, Jiyoung Lee, Jieun Han, Fangyuan Li, Daishun Ling, Wooram Park^#. Tumor microenvironment modulating functional nanoparticles for effective cancer treatments, Tissue Engineering and Regenerative Medicine, 2021, 19(2), 205-219.

97. Jianan Liu#, Fangyuan Li#, Yi Wang#, Limin Pan#, Peihua Lin, Bo Zhang, Yanrong Zheng, Yingwei Xu, Hongwei Liao, Giho Ko, Fan Fei, Cenglin Xu, Yang Du, Kwangsoo Shin, Dokyoon Kim, Sung-Soo Jang, Hee Jung Chung, He Tian, Qi Wang, Wei Guo, Jwa-Min Nam, Zhong Chen*, Taeghwan Hyeon*, Daishun Ling*, A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain, Nature Nanotechnology, 2020, 15, 321–330.

96. Jin Wang#, Yinhang Jia#, Qiyue Wang#, Zeyu Liang#, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai*, Daishun Ling*, An ultra-high field-tailored T1-T2 dual-mode MRI contrast agent for high-performance vascular imaging, Advanced Materials, 2020, 3, 2004917.

95. Xi Hu#, Fan Xia, Jiyoung Lee, Fangyuan Li, Xiaoyang Lu, Xiaozhen Zhuo, Guangjun Nie*, Daishun Ling*, Tailor-made nanomaterials for diagnosis and therapy of pancreatic ductal adenocarcinoma, Advanced Science, 2020, 8, 2002545

94. Meng Zhao#, Zeyu Liang#, Bo Zhang#, Qiyue Wang#, Jiyoung Lee, Fangyuan Li, Qi Wang, Da Ma, Daishun Ling*, A supramolecular container-mediated surface engineering approach for regulating the biological targeting effect of nanoparticles, Nano Letters, 2020, 20(11), 7941–7947

93. Fangyuan Li#, Yueping Qiu#, Fan Xia#, Heng Sun, Hongwei Liao, An Xie, Jiyoung Lee, Peihua Lin, Min Wei, Yanfei Shao, Bo Yang, Qinjie Weng*, Daishun Ling*, Dual detoxification and inflammatory regulation by ceria nanozymes for drug-induced liver injury therapy, Nano Today, 2020, 35, 100925.

92. Peihua Lin, Jiyoung Lee, Ying Chen, Fangyuan Li*, Daishun Ling*, Nanotechnology enabled metal-ion-based disease diagnostics, Science Bulletin, 2020, 65(19), 1587-1589.

91. Yang Du, Chuang Yang, Fangyuan Li*, Hongwei Liao, Zheng Chen, Peihua Lin, Nan Wang, Yan Zhou, Ji Young Lee, Qiang Ding*, Daishun Ling* , Core-shell-satellite nanomaces as remotely controlled self-fueling fenton reagents for imaging-guided triple-negative breast cancer-specific therapy, Small, 2020, 16, 2002537.   Back Inside Cover

74. Jiahe Wu#, Fangyuan Li#, Xi Hu, Jingxiong Lu, Xiaolian Sun, Jianqing Gao*, Daishun Ling*, Responsive assembly of silver nanoclusters with a biofilm locally amplified bactericidal effect to enhance treatments against multi-drug-resistant bacterial infections, ACS Central Science, 2019, 5(8), 1366-1376

73. Qinjie Weng#, Xi Hu#, Jiahuan Zheng#, Fan Xia#, Nan Wang, Hongwei Liao, Ying Liu, Dokyoon Kim, Jianan Liu, Fangyuan Li, Qiaojun He, Bo Yang, Chunying Chen, Taeghwan Hyeon, Daishun Ling*, Toxicological risk assessments of iron oxide nanocluster- and gadolinium-based T1 MRI contrast agents in renal failure rats, ACS Nano, 2019, 13(6), 6801-6812

72. Fangyuan Li#, Zeyu Liang#, Jianan Liu#, Jihong Sun, Xi Hu, Meng Zhao, Jiaxin Liu, Ruiliang Bai, Dokyoon Kim, Xiaolian Sun, Taeghwan Hyeon, Daishun Ling*, Dynamically reversible iron oxide nanoparticle assemblies for targeted amplification of T1-weighted magnetic resonance imaging of tumors, Nano Letters, 2019, 19(7), 4213-4220   Front Cover

71. Haibin Wu#, Fangyuan Li#, Wei Shao, Jianqing Gao*, Daishun Ling*, Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel, ACS Central Science, 2019, 5(3), 477-485   Front Cover

70. Tianyuan Zhang#, Fangyuan Li#, Qianhao Xu#, Qiyue Wang#, Xinchi Jiang#, Zeyu Liang, Hongwei Liao, Xianglei Kong, Jianan Liu, Honghui Wu, Danping Zhang, Changhua An, Liang Dong, Yang Lu, Hongcui Cao, Dokyoon Kim, Jihong Sun, Taeghwan Hyeon, Jianqing Gao*, Daishun Ling*, Ferrimagnetic nanochains-based mesenchymal stem cell engineering for highly efficient post-stroke recovery, Advanced Functional Materials, 2019, 29(24), 1900603

69. Hongwei Liao, Zeyu Liang, Nan Wang, Min Wei, Ying Chen, Fangyuan Li*, Daishun Ling*, Dynamic supraparticles for the treatment of age-related diseases, Science Bulletin, 2019, 64(24), 1850-1874.

68. Yuhuan Li#, Nan Wang#, Xumin Huang, Fangyuan Li, Thomas P. Davis, Ruirui Qiao*, Daishun Ling*, Polymer assisted magnetic nanoparticle assemblies for biomedical applications, ACS Applied Bio Materials, 2020, 3(1), 121-142

59. Fangyuan Li#, Yang Du#, Jianan Liu#, Heng Sun, Jin Wang, Ruiqing Li, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling*, Responsive assembly of upconversion nanoparticles for pH-activated and near-infrared-triggered photodynamic therapy of deep tumors, Advanced Materials, 2018, 30(35), 1802808 Frontispiece Cover

58. Jingxiong Lu, Jihong Sun, Fangyuan Li, Jin Wang, Jianan Liu, Dokyoon Kim, Chunhai Fan, Taeghwan Hyeon, Daishun Ling*, Highly sensitive diagnosis of small hepatocellular carcinoma using pH-responsive iron oxide nanocluster assemblies，Journal of the American Chemical Society, 2018, 140 (32), 10071–10074

57. Shuaifei Wang#, Fangyuan Li#, Ruirui Qiao#, Xi Hu, Hongwei Liao, Lumin Chen, Jiahe Wu, Haibin Wu, Meng Zhao, Jianan Liu, Rui Chen, Xibo Ma, Dokyoon Kim, Jihong Sun, Thomas P. Davis, Chunying Chen, Jie Tian, Taeghwan Hyeon, Daishun Ling*, Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics, ACS Nano, 2018, 12 (12), 12380–12392

56. Qing Chen#, Yang Du#, Kai Zhang#, Zeyu Liang#, Jinquan Li, Hao Yu, Rong Ren, Jin Feng, Zhiming Jin, Fangyuan Li, Jihong Sun, Min Zhou, Qinggang He, Xiaolian Sun, Hong Zhang, Mei Tian*, Daishun Ling*, Tau-targeted multifunctional nanocomposite for combinational therapy of alzheimer's disease, ACS Nano, 2018,12,1321-1338

55. Xi Hu#, Jihong Sun#, Fangyuan Li#, Ruiqing Li, Jiahe Wu, Jie He, Nan Wang, Jianan Liu, Shuaifei Wang, Fei Zhou, Xiaolian Sun, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling*, Renal-clearable hollow bismuth subcarbonate nanotubes for tumor targeted computed tomography imaging and chemoradiotherapy, Nano Letters, 2018, 18, 1196-1204

54. Xi Hu, Fangyuan Li*, Shuying Wang, Fan Xia, Daishun Ling*, Biological stimulus-driven assembly/disassembly of functional nanoparticles for targeted delivery, controlled activation and bioelimination，Advanced Healthcare Materials, 2018, 1800359   Front Cover                                     

53. Jingxiong Lu, Jin Wang, Daishun Ling*, Surface engineering of nanoparticles for targeted delivery to hepatocellular carcinoma, Small, 2018, 14, 1702037

41. Zejun Wang#, Yao Fu#, Zhengzhong Kang#, Xiaoguo Liu#, Nan Chen*, Qi Wang, Yaoquan Tu, Lihua Wang, Shiping Song, Daishun Ling, Haiyun Song, Xueqian Kong*, Chunhai Fan*, Organelle-specific triggered release of immunostimulatory oligonucleotides from intrinsically coordinated DNA–metal–organic frameworks with soluble exoskeleton, Journal of American Chemical Society, 2017, 139(44), 15784-15791

40. Tao Yang#, Hengte Ke#, Qiaoli Wang#, Yong'an Tang, Yibin Deng, Hong Yang, Xiangliang Yang, Peng Yang, Daishun Ling, Chunying Chen, Yuliang Zhao, Hong Wu*, Huabing Chen*, Bifunctional tellurium nanodots for photo-induced synergistic cancer therapy, ACS Nano, 2017, 11(10), 10012-10024

39. Tingting Wang#, Yongyong Song#, Wencheng Zhang#, Zeyu Wu*, Fei Li, Yang Su, Yi Yang, Fangyuan Li, Pengpeng Chen, Jing Wang, Qiang Wu, Xiaolian Sun, Yang Lu*, Daishun Ling*, Stable gold nanorods conjugated liposomal podophyllotoxin nanocomposites for synergistic chemo-photothermal cancer therapy, Journal of Biomedical Nanotechnology, 2017, 13(11), 1435-1445

38. Fangyuan Li, Zeyu Liang, Daishun Ling*, Smart organic-inorganic nanogels for activatable theranostics, Current Medicinal Chemistry, 2019, 26(8),1366-1376

37. Ye Tian, Xiaoshuang Wei, Zhijian Wang, Pengju Pan*, Fangyuan Li, Daishun Ling, Ziliang Wu*, Qiang Zheng, A facile approach to prepare tough and responsive ultrathin physical hydrogel films as artificial muscles, ACS Applied Materials & Interfaces, 2017, 9(39), 34349–34355

36. Yang Lu#, Yunjun Xu#, Guobing Zhang#, Daishun Ling#, Mingquan Wang, Yong Zhou, YaDong Wu, Tao Wu, Michael J. Hackett, Byung Hyo Kim, Hogeun Chang, Jonghoon Kim, Xintian Hu, Liang Dong, Nohyun Lee, Fangyuan Li, Jiacai He, Li Zhang, Huiqin Wen, Bo Yang, Seung Hong Choi*, Taeghwan Hyeon*, Duohong Zou*, Iron oxide nanoclusters for T1 magnetic resonance imaging of non-human primates, Nature Biomedical Engineering, 2017, 1(8), 637-643

35. Taegyu Kang#, Fangyuan Li#, Seungmin Baik#, Wei Shao, Daishun Ling*, Taeghwan Hyeon*, Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy, Biomaterials, 2017, 136, 98-114

34. Xi Hu#, Fangyuan Li#, Nabila Noor, Daishun Ling*, Platinum drugs: from Pt(II) compounds, Pt(IV) prodrugs, to Pt nanocrystals/nanoclusters, Science Bulletin, 2017, 62(8), 589–596

33. Alessandro Marchetti, Juner Chen, Zhenfeng Pang, Shenhui Li, Daishun Ling, Feng Deng*, Xueqian Kong*, Understanding surface and interfacial chemistry in functional nanomaterials via solid-state NMR, Advanced Materials, 2017, 29(14), 1800359

32. Tianyuan Zhang#, Jiahe Wu#, Qianhao Xu, Xiarong Wang, Jingxiong Lu, Ying Hu, Jun-ichiro Jo, Masaya Yamamoto, Daishun Ling, Yasuhiko Tabata*, Jianqing Gao*, Design of magnetic gene complexes as effective and serum resistant gene delivery systems for mesenchymal stem cells, International Journal of Pharmaceutics, 2017, 520(1-2), 1-13

31. Fangyuan Li, Jingxiong Lu, Xueqian Kong, Taeghwan Hyeon, Daishun Ling*, Dynamic nanoparticle assemblies for biomedical applications, Advanced Materials, 2017, 29(14), 1605897

30. Xiaolian Sun, Xuefeng Yan, Orit Jacobson, Wenjing Sun, Zhantong Wang, Xiao Tong, Yuqiong Xia, Daishun Ling, Xiaoyuan Chen*, Improved tumor uptake by optimizing liposome based RES blockade strategy, Theranostics, 2017, 7(2), 319-328

29. Peng Huang*, Daishun Ling, Jibin Song, Gang Liu, Jin Xie, Nanomaterials for cancer phototheranostics, Journal of Nanomaterials, 2016, 4053976, 1-2

28. Daishun Ling*, Surface ligands in synthesis, modification and assembly of nanoparticles for biomedical applications, Nanomedicine Nanotechnology Biology & Medicine, 2016, 12(2), 461

27. Meng Wang, Ying Li, Mingyi Huang Fu, Yi Xiao, Tianyuan Zhang, Min Han, Donghang Xu, Fangyuan Li, Daishun Ling, Yi Jin*, Jianqing Gao*, Pluronic-attached polyamidoamine dendrimer conjugates overcome drug resistance in breast cancer, Nanomedicine, 2016, 11(22), 2917-2934

26. Hongping Xia#, Fangyuan Li#, Xi Hu#, Wooram Park, Shuaifei Wang, Youngjin Jang, Yang Du, Seungmin Baik, Soojeong Cho, Taegyu Kang, DongHyun Kim, Daishun Ling*, Kam Man Hui*, Taeghwan Hyeon*, pH-sensitive Pt nanocluster assembly overcomes cisplatin resistance and heterogeneous stemness of hepatocellular carcinoma, ACS Central Science, 2016, 2 (11), 802–811

25. Mengzhu Yao, Yulan Hu, Xiaoxia Sheng, Jun Lin, Daishun Ling*, Jianqing Gao*, Toxicity analysis of various pluronic F-68-coated carbon nanotubes on mesenchymal stem cells, Chemico-Biological Interactions, 2016, 250, 47-58

24. Michael A. Boles, Daishun Ling, Taeghwan Hyeon, Dmitri V. Talapin*, The surface science of nanocrystals, Nature Materials, 2016, 15(2), 141-153(ESI 高被引）

23. Peilin Yu#, Jin Li#, Jialin Jiang, Zunquan Zhao, Zhaoyuan Hui, Jun Zhang, Yifan Zheng, Daishun Ling, Lie Wang, Lin-Hua Jiang, Jianhong Luo, Xinqiang Zhu*, Wei Yang*, A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles, Scientific Reports, 2015, 5, 18171

22. Hyunjae Lee#, Youngsik Lee#, Changyeong Song#, Hye Rim Cho, Roozbeh Ghaffari, Tae Kyu Choi, Kyung Hoon Kim, Young Bum Lee, Daishun Ling, Hyuk Lee, Su Jong Yu, Seung Hong Choi, Taeghwan Hyeon*, Dae-Hyeong Kim*, An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment, Nature Communications, 2015, 6, 10059

21. Rui Chen#, Daishun Ling#*, Lin Zhao, Shuaifei Wang, Ying Liu, Ru Bai, Seungmin Baik, Yuliang Zhao, Chunying Chen*, Taeghwan Hyeon*, Parallel comparative studies on mouse toxicity of oxide nanoparticle- and gadolinium-based T1 MRI contrast agents, ACS Nano, 2015, 9(12), 12425-12435

20. Daishun Ling, Nohyun Lee, Taeghwan Hyeon*, Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications, Accounts of Chemical Research, 2015, 48 (5), 1276-1285(ESI 高被引）

19. Yongsheng Yu, Jianpeng Wang, Jiahui Liu, Daishun Ling*, Jiang Xia*, Functional assembly of protein fragments induced by spatial confinement, PLoS ONE, 2015, 10(4), 0122101

18. Nohyun Lee#, Dongwon Yoo#, Daishun Ling, Mi Hyeon Cho, Taeghwan Hyeon*, Jinwoo Cheon*, Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy, Chemical Reviews, 2015, 115 (19), 10637–10689

17. Donghee Son#, Jongha Lee#, Dong Jun Lee#, Roozbeh Ghaffari, Sumin Yun, Seok Joo Kim, Ji Eun Lee, Hye Rim Cho, Soonho Yoon, Shixuan Yang, Seunghyun Lee, Shutao Qiao, Daishun Ling, Sanghun Shin, Jun-Kyul Song, Jaemin Kim, Taeho Kim, Hakyong Lee, Jonghoon Kim, Min Soh, Nohyun Lee, Cheol Seong Hwang, Sangwook Nam, Nanshu Lu, Taeghwan Hyeon*, Seung Hong Choi*, Dae-Hyeong Kim*, Bioresorbable electronic stent integrated with therapeutic nanoparticles for endovascular diseases, ACS Nano, 2015, 9(6), 5937–5946

16. Daishun Ling#, Hongping Xia#, Wooram Park, Michael J. Hackett, Changyeong Song, Kun Na, Kam Man Hui*, Taeghwan Hyeon*, pH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinoma, ACS Nano, 2014, 8(8), 8027-8039

15. Daishun Ling, Michael J. Hackett, Taeghwan Hyeon*, Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles, Nano Today, 2014, 9(4), 457-477

14. Daishun Ling#, Liqian Gao#, Jianpeng Wang, Mohammadreza Shokouhimehr, Jiahui Liu, Yongsheng Yu, Michael J. Hackett, Pui-Kin So, Bo Zheng, Zhongping Yao, Jiang Xia*, Taeghwan Hyeon*, A general strategy for site-directed enzyme immobilization by using NiO nanoparticle decorated mesoporous silica, Chemistry - A European Journal Communication, 2014, 20(26), 7916-7921

13. Wooram Park#, Han Na Yang#, Daishun Ling, Hyeona Yim, Taeghwan Hyeon, Kun Na*, Keun-Hong Park*, Multi-modal transfection agent based on monodisperse magnetic nanoparticles for stem cell gene delivery and tracking, Biomaterials, 2014, 35 (25), 7239-7247

12. Seungho Yu#, Xiaohui Guo#, Daishun Ling#, Dong Young Chung, Aihua Ji, Mohammadreza Shokouhimehr, Taeghwan Hyeon*, Yung-Eun Sung*, Facile synthesis of nanostructural carbon nanotubes/iron oxide hybrids for lithium ion battery anodes, Royal Society of Chemistry Advances, 2014, 4(70), 37365-37370

11. Daishun Ling, Michael J. Hackett, Taeghwan Hyeon*, Cancer imaging: lighting up tumours, Nature Materials, 2014, 13(2), 122-124

10. Daishun Ling#, Wooram Park#, Sin-jung Park, Yang Lu, Kyoung Sub Kim, Michael J. Hackett, Byung Hyo Kim, Hyeona Yim, Yong Sun Jeon, Kun Na*, Taeghwan Hyeon*, Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors, Journal of the American Chemical Society, 2014, 136(15), 5647-5655 (ESI 高被引）