变革性分子前沿科学中心

凌 代 舜 教 授 课 题 组

172. Qilong Li^#, Changjian Li^#, Yueqi Wang^#, Miaomiao Li, Zeyu Liang, Qiyue Wang, Bingzhe Wang, Canyu Huang, Jie Tian*, Fangyuan Li*, and Daishun Ling*, Bimagnetic core/shell nanoprobes with tunable exchange coupling for high resolution and sensitive magnetic particle imaging, Angewandte Chemie International Edition, 2024, 64, e202418015.

171. Peihua Lin^#, Zhouyang Qian^#, Shanbiao Liu^#, Xin Ye^#, Pengpeng Xue, Yangjie Shao, Jing Zhao, Yunan Guan, Zhichao Liu, Yuhua Chen, Qiyue Wang, Zhigao Yi, Mingjian Zhu, Mengfei Yu*, Daishun Ling*, Fangyuan Li*, A single-cell RNA sequencing guided multienzymatic hydrogel design for self-regenerative repair in diabetic mandibular defects, Advanced Materials, 2024, 36, 2410962.

170. Hongli Yang^#, Peihua Lin^#, Bo Zhang, Fangyuan Li*, and Daishun Ling*, A Nucleophilicity-engineered DNA ligation blockade nanoradiosensitizer induces irreversible DNA damage to overcome cancer radioresistance, Advanced Materials, 2024, 36, 2410031.

169. Xi Hu^#, Bo Zhang^#, Miao Zhang^#, Wenshi Liang^#, Bangzhen Hong, Zhiyuan Ma, Jianpeng Sheng, Tianqi Liu, Shengfei Yang, Zeyu Liang, Jichao Zhang, Chunhai Fan, Fangyuan Li,* and Daishun Ling*, An artificial metabzyme for tumour cell specific metabolic therapy, Nature Nanotechnology, 2024, 19, 1712-1722.

168. Xi Hu, Daishun Ling*, Nanotechnology-based tumor metabolic reprogramming: Insights into nutrient-delivery and metabolism reactivation therapy, Acta Pharmaceutica Sinica B, 2024, 14, 4619-4621.

167. Yamin Liu, Dao Shi, Bowen Li, Yimin Jin, Daishun Ling*, Fangyuan Li*, Supramolecular macrocyclic artificial ion channels for biomedical applications, Fundamental Research, 2024, in press.

166. Zeyu Liang^#, Shangzhi Xie^#, Qiyue Wang^#, Bo Zhang^#, Lin Xiao, Chenhan Wang, Xun Liu, Ying Chen, Shengfei Yang, Hui Du, Yufan Qian, Daishun Ling*, Lianming Wu*, Fangyuan Li*, Ligands-induced atomically segregation-tunable alloy nanoprobes for enhanced magnetic resonance imaging, ACS Nano, 2024, 18, 23, 15249–15260.

165. Xun Liu^#, Zeyu Liang^#, Hui Du^#, Bo Zhang, Qiyue Wang, Shangzhi Xie, Lin Xiao, Ying Chen, Yuqi Wang, Fangyuan Li*, Daishun Ling*, A DNA-mediated magnetic-dimer assembly for fault-free ultra-high-field magnetic resonance imaging of tumors, Nano Letters, 2024, 24, 22, 6696–6705.

164. Wei Bian^#, Xi Hu^*#, Ruixue Xiao^#, Rui Yao^#, Bo Zhang, Mingjian Zhu, Tianqi Liu, Yamin Liu, Jing Li, Peihua Lin, An Xie, Fangyuan Li*, and Daishun Ling*, Catalytic dual-mode immunotherapy: anisotropic AuPt heterostructure decorated with starry Pt nanoclusters for robust cancer photometalloimmunotherapy, Advanced Science, 2024, 11,2403116.

163. Hui Du^#, Qiyue Wang^#, Bo Zhang^#, Zeyu Liang, Canyu Huang, Dao Shi, Fangyuan Li*, and Daishun Ling*, Structural defect-enabled magnetic neutrality nanoprobes for ultra-high-field magnetic resonance imaging of isolated tumor cells in vivo, Advanced Materials, 2024, 36, 2401538.

162. Zongfu Pan^#, Xixuan Lu^#, Xi Hu^#, Ruixi Yu, Yulu Che, Jie Wang, Lin Xiao, Jianqiang Chen, Xiaofen Yi, Zhuo Tan, Fangyuan Li, Daishun Ling*, Ping Huang*, Minghua Ge*, Disrupting glycolysis and DNA repair in anaplastic thyroid cancer with nucleus-targeting platinum nanoclusters, Journal of Controlled Release, 2024, 369, 517-530.

161. Jun Hyeok Hana^#, Hee Seung Seo^#, Jiyoung Lee^#, Zheng Chen^#, Qiyue Wang, Yun Young Lee, Na Kyeong Lee, Jeon Min Kang, Song Hee Kim, Hwichan Hong, Jung Hoon Park, Yuanzhe Piao, Fangyuan Li, Kun Na, Chun Gwon Park*, Wooram Parka*, and Daishun Ling*, An electro ferroptotic nanoammunition enables image guided, spatiotemporally controlled cancer ferroptosis induction via irreversible electroporation, Chemical Engineering Journal, 2024, 487, 150366.

160. Peihua Lin^#, Bo Zhang^#, Hongli Yang, Shengfei Yang, Pengpeng Xue, Ying Chen, Shiyi Yu, Jichao Zhang, Yixiao Zhang, Liwei Chen, Chunhai Fan, Fangyuan Li*, Daishun Ling*，An artificial protein modulator reprogramming neuronal protein functions，Nature Communications，2024, 15, 2039.

159. Zeyu Liang^#, Lin Xiao^#, Qiyue Wang^#, Bo Zhang, Wenkui Mo, Shangzhi Xie, Xun Liu, Ying Chen, Shengfei Yang, Pengzhan Wang, Fangyuan Li*, Daishun Ling*,   Ligand-mediated magnetism-conversion nanoprobes for activatable ultra-high field magnetic resonance imaging, Angewandte Chemie International Edition, 2024, 63, e202318948.

1‍58. Mengmeng Xia^#, Qiyue Wang^#, Yamin Liu^#, Chunyan Fang^#, Bo Zhang, Shengfei Yang, Fu Zhou, Peihua Lin, Mingzheng Gu, Canyu Huang, Xiaojun Zhang, Fangyuan Li*, Hongying Liu*, Guangfeng Wang*, Daishun Ling*, Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy, Nature Communications, 2024, 15, 460.

157. Qiyue Wang^#, Tao Wang^#, Shengfei Yang^#, Hui Du, Bo Zhang, Sirui Cui, Daishun Ling*, and Fangyuan Li*, Highly sensitive diagnosis of extracellular calcium ions associated brain diseases using Ca²⁺-dependent T2-T1 switchable magnetic nanosensors, Advanced Functional Materials, 2024, 34, 2313286.

156. Ying Chen^#, Zeyu Liang^#, Qiyue Wang, Lin Xiao, Shangzhi Xie, Shengfei Yang, Xun Liu, Daishun Ling*, Fangyuan Li*, Alpha-synuclein oligomers driven T1-T2 switchable nanoprobes for early and accurate diagnosis of parkinson’s disease, Advanced Materials, 2024, 36, 2310404.

134. Min Wei^#, Jiahe Wu^#, Heng Sun^#, Bo Zhang^#, Xi Hu, Qiyue Wang, Bowen Li, Lilan Xu, Teng Ma, Jianqing Gao*, Fangyuan Li*, Daishun Ling*, An enzymatic antibiotic adjuvant modulates the infectious microenvironment to overcome antimicrobial resistance of pathogens, Small, 2023, 2205471. Back Cover

133. Fangyuan Li^#, Heng Sun^#, Jiafeng Ren^#, Bo Zhang^#, Xi Hu, Chunyan Fang, Jiyoung Lee, Hongzhou Gu, Daishun Ling*, A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance, Nature Communications, 2022, 13 (1), 1-16.

132. Xi Hu^#, Yu Sun^#, Xiaoqi Zhou, Bo Zhang, Hanxi Guan, Fan Xia, Shuangying Gui, Xueqian Kong, Fangyuan Li*, and Daishun Ling*, Insight into drug loading regulated micellar rigidity by nuclear magnetic resonance, ACS Nano, 2022, 16 (12), 21407-21416.

131. Hui Du^#, Qiyue Wang^#, Zeyu Liang, Qilong Li, Fangyuan Li^*, Daishun Ling^*. Designed fabrication of magnetic nanoprobes for ultra-high-field magnetic resonance imaging, Nanoscale, 2022, 14 (47), 17483-17499.

130. Guanhua Xu, Mengmeng Li, Qiyue Wang, Feng Feng, Qi Lou, Yi Hou, Junfeng Hui, Peisen Zhang, Li Wang, Li Yao*, Shijie Qin, Xiaoping Ouyang, Dazhuan Wu, Daishun Ling* and Xiuyu Wang*. A dual-kinetic control strategy for designing nano-metamaterials：novel class of metamaterials with both characteristic and whole sizes of nanoscale, Advanced Science, 2022, 2205595.

129. Lingxiao Zhang^#, Jing Zhao^#, Xi Hu^#, Chenhan Wang^#, Yingbo Jia, Chaojie Zhu, Shangzhi Xie, Jiyoung Lee, Fangyuan Li^*, and Daishun Ling^*. A peritumorally injected immunomodulating adjuvant elicits robust and safe metalloimmunotherapy against solid tumors, Advanced Materials, 2022, 2206915.

128. Yamin Liu^#, Qiyue Wang^#, Fangyuan Li, Daishun Ling^*. Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy, Acta Pharmaceutica Sinica B, 2022, 12 (10), 4008.

127. Fan Xia^#, Xi Hu^#, Bo Zhang^#, Xun Wang^#, Yunan Guan, Peihua Lin, Zhiyuan Ma, Jianpeng Sheng, Daishun Ling^*, and Fangyuan Li^*. Ultrasmall ruthenium nanoparticles with boosted antioxidant activity upregulate regulatory T cells for highly efficient liver injury therapy, ‍Small, 2022, 18 (29), 2201558.

126. Haibin Wu^#, Fan Xia^#, Lingxiao Zhang^#, Chunyan Fang, Jiyoung Lee, Linji Gong, Jianqing Gao^*, Daishun Ling^*, Fangyuan Li^*. A ROS-sensitive nanozyme-augmented photoacoustic nanoprobe for early diagnosis and therapy of acute liver failure, Advanced Materials, 2022, 34 (7), 2108348.

125. Xi Hu^#, Nan Wang^#, Xia Guo^#, Zeyu Liang^#, Heng Sun, Hongwei Liao, Fan Xia, Yunan Guan, Jiyoung Lee, Daishun Ling^*, Fangyuan Li^*. A sub-nanostructural transformable nanozyme for tumor photocatalytic therapy, Nano-Micro Letters, 2022, 14 (1), 101.

124. Qiyue Wang^#, Fangyuan Li^#*, Zeyu Liang, Hongwei Liao, Bo Zhang, Peihua Lin, Xun Liu, Shen Hu, Jiyoung Lee, Daishun Ling^*. A K⁺-sensitive AND-gate dual-mode imaging probe for simultaneous tumor imaging and malignancy identification, National Science Review, 2022, 9(7), nwac080.

123. Daishun Ling^*, Guangjun Nie^*, Editorial to dynamic nanoassembly-based drug delivery systems, Advanced Drug Delivery Reviews, 2022, 114345, in press. https://doi.org/10.1016/j.addr.2022.114345

122. Youkun Zheng^#，Min Wei^#，Haibin Wu，Fangyuan Li^*，Daishun Ling^*，Antibacterial metal nanocluster, Journal of Nanobiotechnology, 2022, 20 (1), 1-19.

121. 李方园，王绮玥，樊春海，凌代舜，DNA 介导的功能性纳米组装体及其生物医学应用进展，中国基础科学，2022，已录用。

120. 王绮玥^#，夏凡^#，李方园，戴志飞，凌代舜，纳米影像探针发展现状与未来趋势，中国基础科学，2022，已录用。

116. Qinjie Weng^#, Heng Sun^#, Chunyan Fang^#, Fan Xia, Hongwei Liao, Jiyoung Lee, Jincheng Wang, An Xie, Jiafeng Ren, Xia Guo, Fangyuan Li, Bo Yang, Daishun Ling^*. Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics, Nature Communications, 2021, 12, 1436.

115. Heng Sun^#, Yan Zhong^#, Xiandi Zhu^#, Hongwei Liao^#, Jiyoung Lee, Ying Chen, Lijuan Ma, Jiafeng Ren, Meng Zhao, Mengjiao Tu, Fangyuan Li, Hong Zhang, Mei Tian^*, Daishun Ling^*. A tauopathy-homing and autophagy-activating nanoassembly for specific clearance of pathogenic tau in alzheimer's disease. ACS Nano, 2021, 15(3), 5263-5275.

114. Anran Yuan^#, Fan Xia^#, Qiong Bian, Haibin Wu, Yueting Gu, Tao Wang, Ruxuan Wang, Lingling Huang, Qiaoling Huang, Yuefeng Rao, Daishun Ling, Fangyuan Li^*, Jianqing Gao^*. Ceria nanozymes-integrated microneedles reshape the perifollicular microenvironment for androgenetic alopecia treatment, ACS Nano, 2021, 15(8), 13759-13769.

16. Peihua Lin^#, Mengda Cao^#, Fan Xia, Hongwei Liao, Heng Sun, Qiyue Wang, Jiyoung Lee, Yan Zhou, Yunan Guan, Cheng Zhang, Zhiqiang Xu, Fangyuan Li^*, Ji-Fu Wei^*, Daishun Ling^*. A phosphatase-mimetic nano-stabilizer of mast cells for long-term prevention of allergic disease, Advanced Science, 2021, 8(8), 2004115.

113. Ting Huang^# , Tianyuan Zhang^#* , Xinchi Jiang, Ai Li, Yuanqin Su, Qiong Bian, Honghui Wu, Ruyi Lin, Ni Li, Hongcui Cao, Daishun Ling, Jinqiang Wang, Yasuhiko Tabata, Zhen Gu^*, Jianqing Gao^*. Iron oxide nanoparticles augment the intercellular mitochondrial transfer–mediated therapy, Science Advances, 2021, 7(40), eabj0534.

112. Seungyong Shin, Jiyoung Lee, Jieun Han, Fangyuan Li, Daishun Ling, Wooram Park^#. Tumor microenvironment modulating functional nanoparticles for effective cancer treatments, Tissue Engineering and Regenerative Medicine, 2021, 19(2), 205-219.

111. Daishun Ling^*. The visible medicine?, Journal of Controlled Release, 2021, 339, 416-417.

110. Daishun Ling^*. Dynamic nanoassembly-based drug delivery systems on the horizon, Journal of Controlled Release, 2021, 339, 547-552.

109. Xia Guo^#, Hongwei Liao^#, Jiaming Tian^#, Chuang Yang, Fan Xia, Wenshi Liang, Nan Wang, Pin Li, Bo Zhang, Linji Gong, Xi Hu, Liang Zhang, Fangyuan Li^*, Daishun Ling^*. A bimetallic nanocatalyst for light-free oxygen sensitization therapy, Cell Reports Physical Science, 2021, 2(8), 100538.

108. Qiaolin Wei^#, Jian He^#, Shuaifei Wang^#, Shiyuan Hua, Yuchen Qi, Fangyuan Li, Daishun Ling^*, Min Zhou^*. Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy, Journal of Nanobiotechnology, 2021, 19, 155.

107. Yixuan Guo^#, Yu Liu^#, Wei Wu^#, Daishun Ling, Qiao Zhang, Peng Zhao^*, Xi Hu^*. Indoleamine 2,3-dioxygenase (Ido) inhibitors and their nanomedicines for cancer immunotherapy, Biomaterials, 2021, 276, 121018.

106. Qiyue Wang#, Zeyu Liang#, Fangyuan Li*, Jiyoung Lee, Liang Ee Low, Daishun Ling*. Dynamically Switchable Magnetic Resonance Imaging Contrast Agents, Exploration, 2021, 1(2), 20210009.

105. Xue Xia, Bingyang Shi^*, Lei Wang, Yang Liu, Yan Zou, Yun Zhou, Yu Chen, Meng Zheng, Yingfang Zhu, Jingjing Duan, Siyi Guo, Ho Won Jang, Yuchen Miao, Kelong Fan, Feng Bai, Wei Tao, Yong Zhao, Qingyu Yan, Gang Cheng, Huiyu Liu, Yan Jiao, Shanhu Liu, Yuanyu Huang, Daishun Ling, Wenyi Kang, Xue Xue, Daxiang Cui, Yongwei Huang, Zongqiang Cui, Xun Sun, Zhiyong Qian, Zhen Gu, Gang Han, Zhimou Yang, David Tai Leong, Aiguo Wu, Gang Liu, Xiaogang Qu, Youqing Shen, Qiangbin Wang, Gregory V. Lowry, Ertao Wang, Xing-Jie Liang, Jorge Gardea-Torresdey, Guoping Chen, Wolfgang J. Parak, Paul S. Weiss, Lixin Zhang, Martina M. Stenzel, Chunhai Fan, Ashley I. Bush, Gaiping Zhang, Christopher P. L. Grof, Xuelu Wang, David W. Galbraith, Ben Zhong Tang, Christina E. Offler^*, John W. Patrick^*, Chun-Peng Song^*. From mouse to mouse-ear cress: nanomaterials as vehicles in plant biotechnology, Exploration, 2021, 1(1), 9-20.

104. Sadia Nadeem^#, Chuang Yang^#, Yang Du^#, Fangyuan Li^*, Zheng Chen, Yan Zhou, Ji Young Lee, Qiang Ding^*, Daishun Ling^*. A virus-spike tumor-activatable pyroptotic agent, Small, 2021, 17(8), 2006599.

103. Ai Li^#, Tianyuan Zhang^#, Ting Huang, Ruyi Lin, Jiafu Mu, Yuanqin Su, Hao Sun, Xinchi Jiang, Honghui Wu, Donghang Xu, Hongcui Cao, Xiaoyi Sun, Daishun Ling, Jianqing Gao^*. Iron oxide nanoparticles promote Cx43-overexpression of mesenchymal stem cells for efficient suicide gene therapy during glioma treatment, Theranostics, 2021, 11(17), 8254-8269.

102. Liang Ee Low^#, Qiyue Wang^#, Ying Chen, Peihua Lin, Shengfei Yang, Linji Gong, Jiyoung Lee, Sangeetaprivya P. Siva, Bey-Hing Goh, Fangyuan Li^*, Daishun Ling^*, Microenvironment-tailored nanoassemblies for the diagnosis and therapy of neurodegenerative diseases, Nanoscale, 2021, 13(23), 10197-10238.

101. Ying Chen^#, Min Wei, Jiyoung Lee, Jing Zhao, Peihua Lin, Qiyue Wang, Fangyuan Li^*, Daishun Ling^*, Neurodegenerative disease diagnosis via ion level detection in the brain, Advanced NanoBiomed Research, 2021, 1(8), 2100007.

1‍00. Min Wei^#, Jiyoung Lee^#, Fan Xia, Peihua Lin, Xi Hu, Fangyuan Li^*, Daishun Ling^*, Chemical design of nanozymes for biomedical applications, Acta Biomaterialia, 2021, 126, 15-30.

99. Sadia Nadeem^#, Zheng Chen^#, Min Wei, Fangyuan Li^*, Daishun Ling^*. Nanomedicine induced pyroptosis for cancer therapy. Nanomedicine, 2021, 16(13), 1071-1074.