变革性分子前沿科学中心

凌 代 舜 教 授 课 题 组

172. Qilong Li^#, Changjian Li^#, Yueqi Wang^#, Miaomiao Li, Zeyu Liang, Qiyue Wang, Bingzhe Wang, Canyu Huang, Jie Tian*, Fangyuan Li*, and Daishun Ling*, Bimagnetic core/shell nanoprobes with tunable exchange coupling for high resolution and sensitive magnetic particle imaging, Angewandte Chemie International Edition, 2024, 64, e202418015.

171. Peihua Lin^#, Zhouyang Qian^#, Shanbiao Liu^#, Xin Ye^#, Pengpeng Xue, Yangjie Shao, Jing Zhao, Yunan Guan, Zhichao Liu, Yuhua Chen, Qiyue Wang, Zhigao Yi, Mingjian Zhu, Mengfei Yu*, Daishun Ling*, Fangyuan Li*, A single-cell RNA sequencing guided multienzymatic hydrogel design for self-regenerative repair in diabetic mandibular defects, Advanced Materials, 2024, 36, 2410962.

170. Hongli Yang^#, Peihua Lin^#, Bo Zhang, Fangyuan Li*, and Daishun Ling*, A Nucleophilicity-engineered DNA ligation blockade nanoradiosensitizer induces irreversible DNA damage to overcome cancer radioresistance, Advanced Materials, 2024, 36, 2410031.

169. Xi Hu^#, Bo Zhang^#, Miao Zhang^#, Wenshi Liang^#, Bangzhen Hong, Zhiyuan Ma, Jianpeng Sheng, Tianqi Liu, Shengfei Yang, Zeyu Liang, Jichao Zhang, Chunhai Fan, Fangyuan Li,* and Daishun Ling*, An artificial metabzyme for tumour cell specific metabolic therapy, Nature Nanotechnology, 2024, 19, 1712-1722.

168. Xi Hu, Daishun Ling*, Nanotechnology-based tumor metabolic reprogramming: Insights into nutrient-delivery and metabolism reactivation therapy, Acta Pharmaceutica Sinica B, 2024, 14, 4619-4621.

167. Yamin Liu, Dao Shi, Bowen Li, Yimin Jin, Daishun Ling*, Fangyuan Li*, Supramolecular macrocyclic artificial ion channels for biomedical applications, Fundamental Research, 2024, in press.

166. Zeyu Liang^#, Shangzhi Xie^#, Qiyue Wang^#, Bo Zhang^#, Lin Xiao, Chenhan Wang, Xun Liu, Ying Chen, Shengfei Yang, Hui Du, Yufan Qian, Daishun Ling*, Lianming Wu*, Fangyuan Li*, Ligands-induced atomically segregation-tunable alloy nanoprobes for enhanced magnetic resonance imaging, ACS Nano, 2024, 18, 23, 15249–15260.

165. Xun Liu^#, Zeyu Liang^#, Hui Du^#, Bo Zhang, Qiyue Wang, Shangzhi Xie, Lin Xiao, Ying Chen, Yuqi Wang, Fangyuan Li*, Daishun Ling*, A DNA-mediated magnetic-dimer assembly for fault-free ultra-high-field magnetic resonance imaging of tumors, Nano Letters, 2024, 24, 22, 6696–6705.

164. Wei Bian^#, Xi Hu^*#, Ruixue Xiao^#, Rui Yao^#, Bo Zhang, Mingjian Zhu, Tianqi Liu, Yamin Liu, Jing Li, Peihua Lin, An Xie, Fangyuan Li*, and Daishun Ling*, Catalytic dual-mode immunotherapy: anisotropic AuPt heterostructure decorated with starry Pt nanoclusters for robust cancer photometalloimmunotherapy, Advanced Science, 2024, 11,2403116.

163. Hui Du^#, Qiyue Wang^#, Bo Zhang^#, Zeyu Liang, Canyu Huang, Dao Shi, Fangyuan Li*, and Daishun Ling*, Structural defect-enabled magnetic neutrality nanoprobes for ultra-high-field magnetic resonance imaging of isolated tumor cells in vivo, Advanced Materials, 2024, 36, 2401538.

162. Zongfu Pan^#, Xixuan Lu^#, Xi Hu^#, Ruixi Yu, Yulu Che, Jie Wang, Lin Xiao, Jianqiang Chen, Xiaofen Yi, Zhuo Tan, Fangyuan Li, Daishun Ling*, Ping Huang*, Minghua Ge*, Disrupting glycolysis and DNA repair in anaplastic thyroid cancer with nucleus-targeting platinum nanoclusters, Journal of Controlled Release, 2024, 369, 517-530.

161. Jun Hyeok Hana^#, Hee Seung Seo^#, Jiyoung Lee^#, Zheng Chen^#, Qiyue Wang, Yun Young Lee, Na Kyeong Lee, Jeon Min Kang, Song Hee Kim, Hwichan Hong, Jung Hoon Park, Yuanzhe Piao, Fangyuan Li, Kun Na, Chun Gwon Park*, Wooram Parka*, and Daishun Ling*, An electro ferroptotic nanoammunition enables image guided, spatiotemporally controlled cancer ferroptosis induction via irreversible electroporation, Chemical Engineering Journal, 2024, 487, 150366.

160. Peihua Lin^#, Bo Zhang^#, Hongli Yang, Shengfei Yang, Pengpeng Xue, Ying Chen, Shiyi Yu, Jichao Zhang, Yixiao Zhang, Liwei Chen, Chunhai Fan, Fangyuan Li*, Daishun Ling*，An artificial protein modulator reprogramming neuronal protein functions，Nature Communications，2024, 15, 2039.

159. Zeyu Liang^#, Lin Xiao^#, Qiyue Wang^#, Bo Zhang, Wenkui Mo, Shangzhi Xie, Xun Liu, Ying Chen, Shengfei Yang, Pengzhan Wang, Fangyuan Li*, Daishun Ling*,   Ligand-mediated magnetism-conversion nanoprobes for activatable ultra-high field magnetic resonance imaging, Angewandte Chemie International Edition, 2024, 63, e202318948.

1‍58. Mengmeng Xia^#, Qiyue Wang^#, Yamin Liu^#, Chunyan Fang^#, Bo Zhang, Shengfei Yang, Fu Zhou, Peihua Lin, Mingzheng Gu, Canyu Huang, Xiaojun Zhang, Fangyuan Li*, Hongying Liu*, Guangfeng Wang*, Daishun Ling*, Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy, Nature Communications, 2024, 15, 460.

157. Qiyue Wang^#, Tao Wang^#, Shengfei Yang^#, Hui Du, Bo Zhang, Sirui Cui, Daishun Ling*, and Fangyuan Li*, Highly sensitive diagnosis of extracellular calcium ions associated brain diseases using Ca²⁺-dependent T2-T1 switchable magnetic nanosensors, Advanced Functional Materials, 2024, 34, 2313286.

156. Ying Chen^#, Zeyu Liang^#, Qiyue Wang, Lin Xiao, Shangzhi Xie, Shengfei Yang, Xun Liu, Daishun Ling*, Fangyuan Li*, Alpha-synuclein oligomers driven T1-T2 switchable nanoprobes for early and accurate diagnosis of parkinson’s disease, Advanced Materials, 2024, 36, 2310404.

^{155. Xi Hu#, Pengzhan Wang#, Canyu Huang, Chunyan Fang, Fangyuan Li*, Daishun Ling*,} The role of ligands on synthesis, functional control, and biomedical applications of near-infrared light-responsive metal-based nanoparticles, Coordination Chemistry Reviews, 2023, 502, 215632.

^{154. Ana Beloqui, Daishun Ling, Devika S Manickam, Editorial - JCR EBM SI, Journal of Controlled Release, Published online December 1, 2023. doi:10.1016/j.jconrel.2023.11.059}

153. Jing Zhao^#, Zheng Chen^#, Shanbiao Liu^#, Pin Li, Shiyi Yu, Daishun Ling*, Fangyuan Li*, Nano-bio interactions between 2D nanomaterials and mononuclear phagocyte system cells, BMEMat, 2023, 2, e12066.

152. Ran Xu^#, Sijie Zhang^#, Peixia Wang^#, Ruofei Zhang, Peihuan Lin, Yang Wang, Lizeng Gao, Hui Wei, Xiaodong Zhang, Daishun Ling, Xiyun Yan, Kelong Fan*, Nanozyme-based strategies for efficient theranostics of brain diseases, Coordination Chemistry Reviews, 2023, 501, 215519.

151. Jing Zhao^#, Lingxiao Zhang^#, Pin Li, Shanbiao Liu, Shiyi Yu, Zheng Chen, Mingjian Zhu, Shangzhi Xie, Daishun Ling*, Fangyuan Li*, An immunomodulatory zinc-alum/ovalbumin nanovaccine boosts cancer metalloimmunotherapy through erythrocyte-assisted cascade immune activation, Advanced Science, 2023, 202307389.

150. Pin Li^#, Zheng Chen^#, Fan Xia^#, Nan Wang, Jing Zhao, Xi Hu, Mingjian Zhu, Shiyi Yu, Daishun Ling*, Fangyuan Li*, Leveraging coupling effect‐enhanced surface plasmon resonance of ruthenium nanocrystal‐decorated mesoporous silica nanoparticles for boosted photothermal immunotherapy, Advanced Healthcare Materials, 2023, 12, 2302111.

149. Hongwei Liao^#, Shengfei Yang^#, Zeyu Liang, Lin Xiao, Shangzhi Xie, Peihua Lin, Fan Xia, Chunyan Fang, Qian Chen, Daishun Ling*, Fangyuan Li *, A cancer cell selective replication stress nano amplifier promotes replication fork catastrophe to overcome radioresistance, ACS Nano, 2023, 17, 18, 18548–18561.

148.Qian Chen^#, Chunyan Fang^#, Fan Xia^#, Qiyue Wang, Fangyuan Li*, Daishun Ling*, Metal nanoparticles for cancer therapy: precision targeting of DNA damage, Acta Pharmaceutica Sinica B, 2023, 14, 1132-1149.

147. Ruixue Xiao, Jian Zeng**, Fangyuan Li**, and Daishun Ling*, Gold-semiconductor nanohybrids as advanced photo-therapeutics, Nanomedicine, 2023, 18(22), 1585-1606.

146. Yawen Liu^#, Yushu Li^#, Qiyue Wang, Jing Ren, Chao Ye, Fangyuan Li, Shengjie Ling*, Yilun Liu*, and Daishun Ling*，Biomimetic silk architectures outperform animal horns in strength and toughness，Advanced Science，2023, 10, 2303058.

145. Lilan Xu^#, Jiafu Mu^#, Zhiyuan Ma^#, Peihua Lin^#, Fan Xia, Xi Hu, Jiahe Wu, Jian Cao, Shanbiao Liu, Tianchen Huang, Daishun Ling*, Jianqing Gao*, and Fangyuan Li*, Nanozyme-integrated thermoresponsive in situ forming hydrogel enhances mesenchymal stem cell viability and paracrine effect for efficient spinal cord repair，ACS Applied Materials & Interfaces, 2023, 15 (31), 37193-37204.

144. Haibin Wu^#, Min Wei^#, Shen Hu^#, Pu Cheng, Shuhan Shi, Fan Xia, Lenan Xu, Lina Yin, Guang Liang*, Fangyuan Li*, Daishun Ling*, A photomodulable bacteriophage-spike nanozyme enables dually enhanced biofilm penetration and bacterial capture for photothermal-boosted catalytic therapy of MRSA infections, Advanced Science, 2023, 2301694.

143. Dao Shi^#, Nan Wang^#, Jie Zhang^#, Xi Hu, Qiyue Wang, Ruixue Xiao, Baoyue Ding*, Fangyuan Li*, Daishun Ling*, Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy, Nano research, 2023, 1-14.

142. Qiyue Wang^#, Hui Du^#, Fangyuan Li*, and Daishun Ling*, Nano-metamaterial: a state-of-the-art material for magnetic resonance imaging, Small Science, 2023, 2300015.

141. Qiyue Wang, Pengzhan Wang, Canyu Huang, Sirui Cui, Shengfei Yang, Fangyuan Li*, and Daishun Ling*, Inorganic ion-sensitive imaging probes for biomedical applications, Chemical Communications, 2023, 59, 5807-5822.

140. Shengfei Yang^#, Yuqi Wang^#, Qiyue Wang#, Fangyuan Li*, Daishun Ling*, DNA-driven dynamic assembly/disassembly of inorganic nanocrystals for biomedical imaging, Chemical & Biomedical Imaging, 2023, 1 (4), 340-355.

139. Jie Sun^#, Fan Xia^#, Shaoqi Zhang^#, Bo Zhang^#, Yunan Guan, Xi Hu, Pengpeng Xue, Shengfei Yang, Yan Zhou, Daishun Ling*, Fangyuan Li*, A selective nano cell cycle checkpoint inhibitor overcomes leukemia chemoresistance, Small, 2023, e2300736.

138. Chuang Yang^#, Zheng Chen^#, Min Wei^#, Shen Hu^#, Mengyuan Cai, Nan Wang, Yunan Guan, Fangyuan Li*, Qiang Ding* and Daishun Ling*，A Self-amplified ferroptosis nanoagent that inhibits the tumor upstream glutathione synthesis to reverse cancer chemoresistance, Journal of Controlled Release, 2023, 357, 20-30.

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137. Nan Wang, Pin Li, Jing Zhao, Yamin Liu, Xi Hu, Daishun Ling*, Fangyuan Li*, An anisotropic photocatalytic agent elicits robust photoimmunotherapy through plasmonic catalysis-mediated tumor microenvironment modulation, Nano Today, 2023, 50, 101827.

136. Qiyue Wang^#, Bingzhe Wang^#, Dao Shi, Fangyuan Li*, Daishun Ling*, Cerium oxide nanoparticles^_based optical biosensors for biomedical applications, Advanced Sensor Research, 2023, 2(3), 2200065.

135. Qiyue Wang^#, Shengfei Yang^#, Fangyuan Li*, and Daishun Ling*. Nature-inspired K⁺-sensitive imaging probes for biomedical applications, Interdisciplinary Medicine, 2023, e20220004.

134. Min Wei^#, Jiahe Wu^#, Heng Sun^#, Bo Zhang^#, Xi Hu, Qiyue Wang, Bowen Li, Lilan Xu, Teng Ma, Jianqing Gao*, Fangyuan Li*, Daishun Ling*, An enzymatic antibiotic adjuvant modulates the infectious microenvironment to overcome antimicrobial resistance of pathogens, Small, 2023, 2205471. Back Cover

133. Fangyuan Li^#, Heng Sun^#, Jiafeng Ren^#, Bo Zhang^#, Xi Hu, Chunyan Fang, Jiyoung Lee, Hongzhou Gu, Daishun Ling*, A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance, Nature Communications, 2022, 13 (1), 1-16.

132. Xi Hu^#, Yu Sun^#, Xiaoqi Zhou, Bo Zhang, Hanxi Guan, Fan Xia, Shuangying Gui, Xueqian Kong, Fangyuan Li*, and Daishun Ling*, Insight into drug loading regulated micellar rigidity by nuclear magnetic resonance, ACS Nano, 2022, 16 (12), 21407-21416.

131. Hui Du^#, Qiyue Wang^#, Zeyu Liang, Qilong Li, Fangyuan Li^*, Daishun Ling^*. Designed fabrication of magnetic nanoprobes for ultra-high-field magnetic resonance imaging, Nanoscale, 2022, 14 (47), 17483-17499.

130. Guanhua Xu, Mengmeng Li, Qiyue Wang, Feng Feng, Qi Lou, Yi Hou, Junfeng Hui, Peisen Zhang, Li Wang, Li Yao*, Shijie Qin, Xiaoping Ouyang, Dazhuan Wu, Daishun Ling* and Xiuyu Wang*. A dual-kinetic control strategy for designing nano-metamaterials：novel class of metamaterials with both characteristic and whole sizes of nanoscale, Advanced Science, 2022, 2205595.

129. Lingxiao Zhang^#, Jing Zhao^#, Xi Hu^#, Chenhan Wang^#, Yingbo Jia, Chaojie Zhu, Shangzhi Xie, Jiyoung Lee, Fangyuan Li^*, and Daishun Ling^*. A peritumorally injected immunomodulating adjuvant elicits robust and safe metalloimmunotherapy against solid tumors, Advanced Materials, 2022, 2206915.

128. Yamin Liu^#, Qiyue Wang^#, Fangyuan Li, Daishun Ling^*. Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy, Acta Pharmaceutica Sinica B, 2022, 12 (10), 4008.

127. Fan Xia^#, Xi Hu^#, Bo Zhang^#, Xun Wang^#, Yunan Guan, Peihua Lin, Zhiyuan Ma, Jianpeng Sheng, Daishun Ling^*, and Fangyuan Li^*. Ultrasmall ruthenium nanoparticles with boosted antioxidant activity upregulate regulatory T cells for highly efficient liver injury therapy, ‍Small, 2022, 18 (29), 2201558.

126. Haibin Wu^#, Fan Xia^#, Lingxiao Zhang^#, Chunyan Fang, Jiyoung Lee, Linji Gong, Jianqing Gao^*, Daishun Ling^*, Fangyuan Li^*. A ROS-sensitive nanozyme-augmented photoacoustic nanoprobe for early diagnosis and therapy of acute liver failure, Advanced Materials, 2022, 34 (7), 2108348.

125. Xi Hu^#, Nan Wang^#, Xia Guo^#, Zeyu Liang^#, Heng Sun, Hongwei Liao, Fan Xia, Yunan Guan, Jiyoung Lee, Daishun Ling^*, Fangyuan Li^*. A sub-nanostructural transformable nanozyme for tumor photocatalytic therapy, Nano-Micro Letters, 2022, 14 (1), 101.

124. Qiyue Wang^#, Fangyuan Li^#*, Zeyu Liang, Hongwei Liao, Bo Zhang, Peihua Lin, Xun Liu, Shen Hu, Jiyoung Lee, Daishun Ling^*. A K⁺-sensitive AND-gate dual-mode imaging probe for simultaneous tumor imaging and malignancy identification, National Science Review, 2022, 9(7), nwac080.

123. Daishun Ling^*, Guangjun Nie^*, Editorial to dynamic nanoassembly-based drug delivery systems, Advanced Drug Delivery Reviews, 2022, 114345, in press. https://doi.org/10.1016/j.addr.2022.114345

122. Youkun Zheng^#，Min Wei^#，Haibin Wu，Fangyuan Li^*，Daishun Ling^*，Antibacterial metal nanocluster, Journal of Nanobiotechnology, 2022, 20 (1), 1-19.

121. 李方园，王绮玥，樊春海，凌代舜，DNA 介导的功能性纳米组装体及其生物医学应用进展，中国基础科学，2022，已录用。

120. 王绮玥^#，夏凡^#，李方园，戴志飞，凌代舜，纳米影像探针发展现状与未来趋势，中国基础科学，2022，已录用。