Lab of Dynamic Nano AssemblyProf. Daishun Ling's Group
01/24 2019 团队开发了一种肿瘤微环境响应型的超小氧化铁纳米粒子组装体，在肿瘤微酸的环境条件下，组装体可以响应性解组装，使得磁共振T1加权成像的信号增强，从而实现小尺寸原位肝癌的精准诊断。 01/23 2019 铁凋亡（Ferroptosis）作为一种新型铁依赖的细胞死亡通路，近年来受到了各国科研工作者的广泛关注。目前，基于铁凋亡的肿瘤治疗策略主要包括铁基纳米材料的设计和谷胱甘肽过氧化物酶（GPX4）活性抑制的小分子化合物的合成。 01/22 2019 团队开发了一种肿瘤微环境响应型深度光动力治疗药物。该研究团队将上转换纳米粒子（能够被组织穿透力更强的近红外光激发，发射出可见光，进而激发光敏剂）和连接光敏剂分子的pH响应型高分子进行组装得到响应型纳米组装体。 |
 Prof. Daishun Ling (凌代舜) Distinguished professor of Chemistry Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineering National Center for Translational Medicine Shanghai Jiao Tong University, Shanghai, China Address: 800 Dongchuan RD. Minhang District, Shanghai, China Email: dsling@sjtu.edu.cn Web: www.dsling.cn |  Our laboratory is working on the development of smart biomaterials and nanomedicine strategies to assist the diagnosis and treatment of challenging diseases such as cancer and neurodegenerative diseases. We are focusing on the dynamic assembly/disassembly of functional nanoparticles, stimuli-responsive nanomedicines, designed synthesis and surface engineering of functional nanomaterials for biomedical applications. |
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